Identification of the sites of deoxyhaemoglobin PEGylation
نویسندگان
چکیده
منابع مشابه
Identification of the sites of deoxyhaemoglobin PEGylation.
The 2-iminothiolane reaction with protein amino groups adds a spacer arm ending with a thiol group, which can be further treated with molecules carrying a maleimido ring. This approach is currently used for the preparation of a candidate 'blood substitute' in which human Hb (haemoglobin) is conjugated with long chains of PEG [poly(ethylene glycol)]. To identify the thiolation sites by MS, we ha...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2007
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20061556